A general, norbornyl based approach to anti-Bredt alkenes via sequential RCM-fragmentation strategy.
نویسندگان
چکیده
A general protocol for the synthesis of bicyclo[n.3.1]frameworks with bridgehead double bond (anti-Bredt alkenes), from a common, readily available norbornyl precursor, involving sequential ring closure metathesis (RCM) and Wharton fragmentation is outlined.
منابع مشابه
The Type 2 Intramolecular Diels-Alder Reaction: Synthesis and Chemistry of Bridgehead Alkenes.
Anti-Bredt alkenes, bicyclic molecules that contain a bridgehead double bond, were for many years regarded as chemical curiosities. The type 2 intramolecular Diels-Alder (IMDA) reaction provides a one-step entry into this fascinating class of molecules. The reaction has made available numerous anti-Bredt alkenes for structural and chemical studies. X-ray crystallography has revealed the magnitu...
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عنوان ژورنال:
- Chemical communications
دوره 14 شماره
صفحات -
تاریخ انتشار 2002